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3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening /
Kisaalita, William Ssempa
3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening / William Ssempa Kisaalita. - 1st ed. - Boca Raton : CRC Press, 2010. - xiii, 386 p. : ill. ; 20 cm.
Includes bibliographies and index.
Biosensors and bioassays
Target-driven drug discovery
Comparative transcriptional profiling and proteomics
Comparative structure and function
Chemical microenvironmental factors
Spatial and temporal microenvironmental factors
Material physical property and force microenvironmental factors
Proteomics as a promising tool in the search for 3D biomarkers
Readout present and near future
Ready-to-use commercial 3D plates
Challenges to adopting 3D cultures in HTS programs
Cases for 3D cultures in drug discovery
Ideal case study design
"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
9781420073492
Biocapteurs.
Biosensing Techniques.
Biosensors.
615.19 / KIS
3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening / William Ssempa Kisaalita. - 1st ed. - Boca Raton : CRC Press, 2010. - xiii, 386 p. : ill. ; 20 cm.
Includes bibliographies and index.
Biosensors and bioassays
Target-driven drug discovery
Comparative transcriptional profiling and proteomics
Comparative structure and function
Chemical microenvironmental factors
Spatial and temporal microenvironmental factors
Material physical property and force microenvironmental factors
Proteomics as a promising tool in the search for 3D biomarkers
Readout present and near future
Ready-to-use commercial 3D plates
Challenges to adopting 3D cultures in HTS programs
Cases for 3D cultures in drug discovery
Ideal case study design
"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
9781420073492
Biocapteurs.
Biosensing Techniques.
Biosensors.
615.19 / KIS