TY  - BOOK
AU  - Kisaalita, William Ssempa
TI  - 3D cell-based biosensors in drug discovery programs: microtissue engineering for high throughput screening 
SN  - 9781420073492
U1  - 615.19 
PY  - 2010///
CY  - Boca Raton
PB  - CRC Press
KW  -  Biocapteurs
KW  - Biosensing Techniques
KW  - Biosensors
N1  - Includes bibliographies and index; Biosensors and bioassays
Target-driven drug discovery
Comparative transcriptional profiling and proteomics
Comparative structure and function
Chemical microenvironmental factors
Spatial and temporal microenvironmental factors
Material physical property and force microenvironmental factors
Proteomics as a promising tool in the search for 3D biomarkers
Readout present and near future
Ready-to-use commercial 3D plates
Challenges to adopting 3D cultures in HTS programs
Cases for 3D cultures in drug discovery
Ideal case study design
N2  - "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher
ER  -