000			02007nam a2200241Ia 4500
005			20250509114847.0
008			230702s9999 xx 000 0 eng d
020			_a9781420073492 _qpbk.
041			_aeng
082			_a615.19 _bKIS
100			_aKisaalita, William Ssempa
245		0	_a3D cell-based biosensors in drug discovery programs : _bmicrotissue engineering for high throughput screening / _cWilliam Ssempa Kisaalita.
250			_a1st ed.
260			_aBoca Raton : _bCRC Press, _c2010.
300			_axiii, 386 p. : _bill. ; _c20 cm.
504			_aIncludes bibliographies and index.
505			_aBiosensors and bioassays Target-driven drug discovery Comparative transcriptional profiling and proteomics Comparative structure and function Chemical microenvironmental factors Spatial and temporal microenvironmental factors Material physical property and force microenvironmental factors Proteomics as a promising tool in the search for 3D biomarkers Readout present and near future Ready-to-use commercial 3D plates Challenges to adopting 3D cultures in HTS programs Cases for 3D cultures in drug discovery Ideal case study design
520			_a"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
650			_a Biocapteurs.
650			_aBiosensing Techniques.
650			_aBiosensors.
942			_cENG
999			_c55035 _d55035